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Thank you to our sponsors AG1 (Athletic Greens): InsideTracker: Thesis: Supplements from Momentous For the full show notes, visit hubermanlab.com Timestamps (00:00:00) Mood Disorders & Maintaining Mental Health (Protocol 1) (00:07:10) Sponsors (00:11:15) Major Depression (00:18:40) Anti-Self Confabulation (00:21:42) Autonomic (Vegetative) Symptoms of Depression (00:26:58) Norepinephrine, Dopamine & Serotonin (00:31:50) SSRIs (Prozac, Zoloft, etc.): Selective Serotonin Reuptake Inhibitors (00:37:00) Epinephrine/Motor Functions, Dopamine/Motivation & Craving, Serotonin/Emotions (00:39:33) Physical & Emotional Pain are Linked: Substance P (00:41:50) Hormones & Depression: Thyroid & Cortisol (00:46:50) Genetic Susceptibility to Depression: Impact of Stress (00:50:50) Understanding Biological Mechanism Is Key: Recipes versus Skills (00:52:50) Tools for Dealing with Depression: Logic & Implementation (Protocol 2) (00:56:25) Brain Inflammation & Mental State: Cytokines, Prostaglandins, etc

The Middle East and Africa held a 2% share of the market in 2025 and are expected to grow at a notable CAGR of 14.8% during the projection period, driven by expanding healthcare investments and obesity management programs

Our clinical team prioritises safety, transparency, and evidence-based practice, ensuring that each patient receives high-quality care tailored to their individual needs

Liver Health Support The inclusion of the glucagon receptor agonist has shown promise in reducing liver fat, which is crucial for overall metabolic health and longevity